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The triplet combination demonstrated good tolerability, supporting initiation of the randomized portion of the trial.
Inappropriate activation of proteins in this pathway has been shown to occur in many cancers including melanoma, colorectal cancer, non-small cell lung cancer, self liquidating asset definition us gaap thyroid and others. Metastatic melanoma is the most serious and life-threatening type of skin cancer and is associated with low survival rates.
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It also eases some of the pressure to find a partner for binimetinib. The next step would be a new licensing deal for binimetinib which will enable Array to offset some of the cost as well as pursue additional combination regimens. The interim analysis may also support regulatory submissions in other regions. There are a variety of gene mutations that can lead to metastatic melanoma. One patient discontinued treatment with the triplet combination due to treatment-related adverse events.